In vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium

Several studies report flow disturbance and microcirculation disorders upon anesthesia treatment. These alterations are often related to blood rheology changes. In this work, it was attempted make a detailed description of the in erythrocyte mechanical properties by action propofol, remifentanil, vecuronium. For this, an vitro study performed on red cell samples from healthy donors incubated with solutions propofol (4 ?g/mL whole blood), remifentanil (10 ng/mL plasma), vecuronium (0.15 plasma). Erythrocyte viscoelastic parameters were determined octuplicate using Reómetro Eritrocitario. Also, Wilcoxon signed rank-test Yates correction for continuity analyze overall alteration erythrocytes. Statistical analysis showed that three studied anesthetics changed at different parts membrane. results would imply interaction these Finally, could conduce microcirculation. • viscoelasticity measured The be interacting lipid bilayer. cytoskeleton protein. Vecuronium alter